Prevention of Abdominal Aortic Aneurysm Progression by Targeted Inhibition of Matrix Metalloproteinase Activity with Batimastat-Loaded Nanoparticles¶
Abstract¶
Matrix metalloproteinases (MMPs)-mediated extracellular matrix destruction is the major cause of development and progression of abdominal aortic aneurysms (AAA). Systemic treatments of MMP inhibitors have shown effectiveness in animal models but it did not translate to clinical success either due low doses used or systemic side-effects of MMP inhibitors. We propose a targeted nanoparticle based delivery of MMP inhibitor at very low doses to the AAA site. Such therapy will be an attractive option for preventing expansion of aneurysms in patients without systemic side effects.
Bio
Dr. Nasim Nosoudi is an adjunct professor of biomedical engineering at Wright State University. She earned her PhD in Bioengineering from Clemson University, SC, US. She got her MSc in biomedical engineering and BSc in Materials Engineering. Her research interests are in cardiovascular diseases, theranostics and tissue engineering. She has published in journals such as Circulation Journal, Theranostics and the Journal of Controlled Release.